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Leonurine

Leonurine is a pseudoalkaloid that has been isolated from Leonotis leonurus, Leonotis nepetifolia, Leonotis artemisia, Leonurus cardiaca (Motherwort), Leonurus sibiricus, as well as other plants of family Lamiaceae. [citation needed] Leonurine is easily extracted into water.Chemical synthesis. Leonurine can be synthesized starting from eudesmic acid.. Leonurine hydrochloride (LH) is a major alkaloid compound with molecular formula C14 H 21 O 5 N 3 .HCl and MW 311.33 g/mol derived from leonurine. It is extracted from motherwort (Leonurus cardiac)and is known for exerting phytoestrogenic activity [ 80 ]

Leonurine - Wikipedi

Herba leonurine attenuates doxorubicin‐induced apoptosis in H9c2 cardiac muscle cells. European Journal of Pharmacology, 612, 75-79. 10.1016/j.ejphar.2009.03.067 [Google Scholar] Xiong, L. , & Peng, C. (2016). Study on Q‐Marker of Leonurus japonicus and Penthorum chinense based on basic conditions of Q‐Marker Leonurine, a major active alkaloid compound only be found in Leonurus japonicus Houtt, has been successfully extracted and purified. Recent evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress, inflammation, fibrosis, apoptosis, and multiple metabolic disorders Leonurine has cardioprotective effects both in vivo and in vitro [50,79,80] while cysteine analogues are endogenous hydrogen sulfide (H 2 S) modulators and demonstrate protective effects on acute myocardial ischaemia through regulating cysthathionine-γ-lyase pathway [81].Conjugation of leonurine through ester linkage with varied cysteine analogues such as S-allyl-l-cysteine (SAC) (an active. Background: Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates that leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease Leonurine (SCM-198) is a natural product with antioxidant, anti-inflammatory, and cardioprotective activity being investigated for the treatment of cardiovascular disease and stroke. Leonurine suppresses inflammation and oxidative stress, decreasing a number of inflammatory factors, reducing cardiac Nox4 expression, ROS production, NF-KB.

Leonurine has antidepressant effects by improving monoamine neurotransmitters and inhibiting nerve inflammation, it may be one of the effective strategies for the treatment of depression in the future. 2.2.6 Treatment of multiple sclerosis. Multiple sclerosis (MS) is an. Leonurine (1) is the uterotonic principle of Leonurus artemisia. We have developed a simple, high-yield synthetic procedure of 1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 1:1 HMPT-ether as solvent

Wenn nicht anders vermerkt, gelten die angegebenen Daten bei Standardbedingungen . Leonurin ist ein natürliches Alkaloid, welches in verschiedenen Spezies der Pflanzengattung der Löwenohren ( Leonotis) vorkommt. Chemisch gesehen ist Leonurin ein Ester einer aromatischen Carbonsäure, genauer ein Syringasäure - Ester . Leonurus japonicus Leonurine (60 mg/kg) administration for 4 weeks significantly improved the injury of myelin and remarkably decreased the g-ratio compared with the CMS group (Figure 3C-D, F 2,504 = 119.888, P<.01). Leonurine Suppressed Inflammation in the Hippocampus of CMS Mic

SCM-198, 4-Guanidinobutyl 4-hydroxy-3,5-dimethoxybenzoate, 4-Guanidino-1-butanol syringate. CAS Number: 24697-74-3. Molecular Weight: 311.33. Empirical Formula (Hill Notation): C14H21N3O5 Molekulska formula. C 14 H 21 N 3 O 5. Molarna masa. 311.33 g mol −1. Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala. Infobox references. Leonurin je organsko jedinjenje, koje sadrži 14 atoma ugljenika i ima molekulsku masu od 311,334 Da

Leonurine hydrochloride is a synthetic chemical compound based on the structure of leonurine, which is found in motherwort and has been reported to exhibit phytoestrogenic activity. In RAW 264.7 cells and mouse bone marrow monocytes (BMMs), Leonurine hydrochloride suppressed RANKL-induced osteoclastogenesis and actin ring formation in a dose. The Merck Index* Online | Leonurine | Monograph containing literature references, physical and biological properties and relevant informatio Leonurine is a pseudoalkaloid that has been isolated from Leonotis leonurus , Leonotis nepetifolia, Leonotis artemisia, Leonurus cardiaca (Motherwort), Leonurus sibiricus, as well as other plants of family Lamiaceae. Leonurine is easily extracted into water. Read full article at Wikipedia..

Leonurine, a major active alkaloid compound only be found in Leonurus japonicus Houtt, has been successfully extracted and purified. Recent evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress, inflammation, fibrosis, apoptosis, and multiple metabolic disorders. Here, we have reviewed the. Leonurine attenuates hyperalgesia in mice with induced adenomyosis via down-regulating expressions of p-P65, COX-2, and OTR, and could be beneficial for treating adenomyosis. Leonurine exerts antidepressant-like effects, which may be mediated, at least in part, by improving monoamine neurotransmitters and inhibiting neuroinflammation

Leonurine - an overview ScienceDirect Topic

Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is. Leonurine is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol. 益母草碱(Leonurine), 学名3,5-二甲氧基-4-羟基-苯甲酸 (4-胍基)-1-丁酯,常见者为其盐酸盐水合物。提取自唇形科植物 细叶益母草 (Leonurus sibiricus L.)的叶,或 益母草 (L.heterophyllus Sweet),艾蒿益母草 (L. artemisia) 全草。具有活血化淤、利水消肿的作用 Leonurine reportedly displayed anti‐inflammatory function. 15-18 However, we found that leonurine had no effect on T cell response in the periphery, indicating by similar components of CD4 + and CD8 + T cells in the DLN of vehicle‐ and leonurine‐treated EAE mice, as well as similar proliferation, cytokine profile, and ability to induce.

Leonurine hydrochloride. Catalog No. N1392. Add to Compare. Email . Skip to the end of the images gallery. Skip to the beginning of the images gallery. Grouped product items; Size Price Stock Qty; 20mg: $170.00. In stock : Tel: +1-832-696-8203. Email: [email protected] Worldwide Distributors. Bulk Inquiry. Add to Cart Leonurine, which is derived from Leonurus cardiaca, has been implicated in a large range of pharmacological actions . Several studies have shown that it exhibits a wide range of biological activities, including analgesic , anti-inflammatory , anti-tumour and bone protectant activities . These observations suggest benefits of leonurine for the. LEONURINE 09Q5W34QDA Other Structure General Activity Publications Application Names 8: Identifiers 7: Related Substances 1: LEONURINE 09Q5W34QDA Other Details Stereochemistry: ACHIRAL Molecular Formula: C14H21N3O5: Molecular Weight: 311.3342.

Leonurine, a potential drug for the treatment of

1. Leonurine hydrochloride (LH) is derived from an ingredient of Leonurus japonicus Houtt which is widely used for diseases in women. 2. The influence of LH on the activity of cytochrome P450. Leonurine, extracted from Leonurus cardiaca, has been proved to have anti-inflammatory effect. In the present study, we utilized a mouse mastitis model to study the effect of leonurine on LPS-induced mastitis. Leonurine was administered three times during the 24 h after inducing infection in the mammary gland

Video: Leonurine: From Gynecologic Medicine to Pleiotropic Agen

  1. g effect that the leonurine in motherwort has on the nerves may be an important way that it reduces abnormal heart rhythm. It is a strong antioxidant. Oxidative stress has severe effect on the nerves and vascular cells
  2. Leonurine A wide assortment of chemicals and reagents are available for use in biochemistry, molecular biology, and cell biology. Browse effectively through our extensive catalog by selecting appropriate filters on the left for attributes such as product type, application, format, or method of detection
  3. Definition of leonurine in the Definitions.net dictionary. Meaning of leonurine. What does leonurine mean? Information and translations of leonurine in the most comprehensive dictionary definitions resource on the web
  4. As a result, Leonurine is considered to maybe have a direct exciting effect on the respiratory center. 4. Other effects: Small doses of Leonurine are able to induce tensional atony of rabbit isolated intestine and enlarge the amplitude, whereas large doses of Leonurine result in a narrowed amplitude and an increased frequency
  5. Please provide credit to AllAcronyms.com. This work by AllAcronyms.com is licensed under CC BY-ND 4.0. stop animation stop. slide 2 of 3. LE is a shorter form of Leonurine. LE means Leonurine. LE is an abbreviation for Leonurine

Leonurine (LEO, also named as SCM-198) is a natural alkaloid chemically synthesized by our laboratory from Herba leonuri which has long been used in chinese traditional medicine.The studies on LEO. Leonurine (SCM-198), an alkaloid from Herba Leonuri, has been suggested as a novel cardiovascular agent by pharmacology studies in preclinical stage. In present study, we report a simple, rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS) for determination of leonurine in rat plasma Our Leonurine hydrochloride is confirmed by NMR. Order now can get a discount! The BioCrick Provides Reference Standard and Natural Product of CAS:24697-74-3,Leonurine hydrochloride Quality confirmed by HPLC, NMR& MS A molecular entity capable of donating a hydron to an acceptor (Br o nsted base). (via oxoacid ) View more via ChEBI Ontology. ChEBI Ontology. Outgoing. Leonurine ( CHEBI:80843 ) is a trihydroxybenzoic acid ( CHEBI:27115 ) Synonym. Source. Norboldine Leonurine is a guanidine alkaloid shown to have cardioprotective, hypotensive, uterotonic, and neuroprotective effects. 6 Leonurine has been reported to be a constituent of Leonurus cardiaca; however, some assays could not confirm its presence in L. cardiaca. 6 Related alkaloids, including synthetic versions, may act in similar ways 7, 8, 9.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colon. The aim of the present study was to explore the effects of leonurine (YMJ) on inflammation and intestinal microflora in colonic tissues of a dextran sulfate sodium (DSS)‑induced ulcerative colitis (UC) mouse model. Mice were randomly divided into control (n=5), DSS (n=5, treated with DSS) and DSS+YMJ (n=5. Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects

Leonurine Exerts Antidepressant-Like Effects in the

Leonurine (YMJ), as an active ingredient, was first extracted as a TCM from Leonurus heterophyllus (18). YMJ promotes uterine contraction, and prevents osteoporosis, mastitis and myocardial fibrosis(19). The above functions of YMJ maybe associated with its anti‑inflammatory effects. Previous studie Klip Dagga contains more leonurine, a pseudoalkaloid, than any strain of Wild Dagga. Alkaloid-containing plants have been used by humans since ancient times for therapeutic and recreational purposes. They produce euphoric effects when consumed LEONURINE 09Q5W34QDA Other Structure Moieties 1: General Activity Publications Application Record Details Names 8: Identifiers 7: Active Moiety 1: LEONURINE 09Q5W34QDA Other Details Stereochemistry: ACHIRAL. Leonurine is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory. 靶点活性. Autophagy. 体外活性. Leonurine significantly inhibited lipid accumulation and promoted 3H-cholesterol efflux in human THP-1 macrophage-derived foam cells in a concentration-dependent manner. Besides, both the mRNA and.

Leonurine is a pseudoalkaloid extracted from various Leonurus species, including L. sibiricus and L. heterophyllus. 7 Leonurine possesses potent anti-inflammatory, anti-oxidative, and anti-apoptotic activity in multiple diseases. 8-10 Leonurine performs cardioprotective effects against endotoxin, hypoxia, or doxorubicin-induced cardiomyocyte. Leonurine Promotes the Apoptosis Effect of Cisplatin on Cervical Cancer Cells. To observe the role of leonurine on cisplatin-mediated cell apoptosis, the flow cytometry based Annexin-V/PI double staining analysis was utilized. Compared to the control group, leonurine increased the apoptosis in both C33A and MS751 cells

Leonurine ≥98% (HPLC) 24697-74-

  1. Leonurus japonicus houtt, a well-known herb of traditional Chinese medicine, is widely used to treat gynaecological diseases. In this study, a rapid and sensitive liquid chromatography with tandem mass spectrometry method for simultaneously quantifying leonurine and stachydrine, the two main bioactive components in Leonurus japonicus houtt, was developed and validated
  2. Leonurine is an active alkaloid that can be found in some of the species of the Leonurus genus. A good amount of clinical trials and research data portrays a magnificent portfolio of leonurine. It has been identified to show Neuroprotective effects when it comes to ischemic strokes, Alzheimer's disease, and Parkinson's disease
  3. Leonurine could not establish itself as a pharmaceutical agent. Individual evidence ↑ a b Yeung, HW; Kong, YC; Lay, WP; Cheng, KF: The Structure and Biological Effect of Leonurine in Planta Med 31 (1977) 51-56, doi: 10.1055 / s-0028-1097489. ↑ There is not yet a harmonized classification for this substance
  4. Leonurine can significantly inhibit oxygen free radicals in the cells, thereby inhibiting lipid peroxidation in ischemic or hypoxic myocardial cells, reducing the level of MDA (malondialdehyde), which is a product of lipid peroxidation. Leonurine can inhibit myocardial cell apoptosis, and have great value in application of treating heart disease
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Leonurine, a major bioactive component from Herba Leonuri , shows therapeutic potential for cardiovascular disease and stroke prevention in some preclinical experiments. The aim of this study is to characterize metabolites of leonurine in rats using high performance liquid chromatography coupled with tandem mass spectrometry (HPLC/MS/MS) The invention belongs to the field of medicinal chemistry and in particular relates to a leonurine analog and a preparation method thereof. The leonurine analog provided by the invention has a structure of a formula (1). The preparation method comprises the following steps of: combining a Chinese medicinal monomer with an active gas molecule by using a computer simulation aided design, wherein. Stroke is a leading cause of morbidity and mortality globally. Leonurine (also named SCM-198), a compound extracted from Herba leonuri , was effective on the prevention of various cardiovascular and brain diseases. The purpose of this study was to explore the possible therapeutic potential of SCM-198 against ischemia reperfusion injury and underlying mechanisms

Leonurin

Leonurine | C14H21N3O5 | Structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards. Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways. Feng-Lai Yuan , R. Xu , +4 authors Xia L leonurine and VC for O2·(·OH) were 450.16±7.33 -1 and 707.40±4.95 (1238.63±7.16) μmol·L-1, respectively, indicating that the scavenging rate of leonurine towards O2·and OH was comparable to VC (Fig. 2C and 2D). Rota-rod test . The accelerating Rotarod experiments were performed - to investigate the effects of leonurine on moto The invention belongs to a pharmaceutical field of traditional Chinese medicines, and relates to a leonurine preparation method. The leonurine preparation method provided by the invention comprises the following steps of: selecting cheap aminobutyric acid as a raw material, conveniently synthesizing protected aminobutanol by amino protection and reduction reaction,taking a benzyl group as a.

Leonurin - Wikipedi

Leonurine,a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives Di Yanga, Wanwan Jiaa and Yi Zhun Zhua,b* aShanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China, 201203 bSchool of Pharmacy, Macau University of Science and Technology Maca Leonurine (1), an important ingredient in leonurus sibiricus L., can be used for some gynecological disease. We have developed a concise and efficient synthetic route of Leonurine, which can be optimized for mass production. Commercially available compound 6 and 2,3-dihydrofuran (7) were used as starting materials. And the toxicity study on zebrafish shows that Leonurine would promote the. Research showed that leonurine, which is an organic amine alkaloid and has been widely used, is mainly produced by plants in the genus Leonurus [24]. The plants of Labiatae can also produce other. Leonurine (LEO) is a bioactive small molecular compound that has protective effects on the cardiovascular system and prevents the early progression of atherosclerosis; however, it is not clear whether LEO is effective for plaque stability. A novel mouse atherosclerosis model involving tandem stenosis (TS) of the right carotid artery combined with western diet (WD) feeding was used Buy amazing leonurine on Alibaba.com at irresistible offers and enhance your well-being. The proven health benefits of leonurine will leave you with a smile

Leonurine (LEO) is a unique alkaloid isolated from Leonurus japonicus Houtt (a traditional Chinese medicine (TCM)), which has shown a good effect on promoting blood circulation and removing blood stasis. In this study, we explored the protective effect and action mechanism of LEO on huma Leonurine. Leonurine. Leonurine IUPAC name. 4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester. Identifiers CAS number: 24697-74-3. Leonurine is a pseudoalkaloid that has been isolated from Leonotis nepetifolia, Leonotis artemisia, Leonurus cardiaca (Motherwort), Leonurus sibiricus, as well as other plants of family Lamiaceae. 14 relations

Frontiers | Leonurine Regulates Treg/Th17 Balance to

Leonurine Sigma-Aldric

Leonurine [24697-74-3]-Biopurify Phytochemicals Online Sho

Leonurine (1) is the uterotonic principle ofLeonurus artemisia. We have developed a simple, high-yield synthetic procedure of1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 1∶1 HMPT-ether as solvent. The synthetic leonurine showed uterotonic activity in vivo and in vitro Leonurine is a pseudoalkaloid that has been isolated from Leonotis leonurus, Leonotis nepetifolia, Leonotis artemisia, Leonurus cardiaca (Motherwort), Leonurus sibiricus, as well as other plants of family Lamiaceae. Leonurine is easily extracted into water The invention aims to provide a preparation technology of leonurine, which has the advantages of reasonable economy and stable process. The preparation technology provided in the invention, which has the characteristics of cheap prices of initial raw materials and intermediate reagents, mild reaction, and improvement of the overall yield and the product quality through a whole synthetic route.

Myocardial fibrosis (MF) is a pathological process that accelerates cardiac remodeling in myocardial infarction (MI), and miR-29 has become one of the foci of research into MF. As an alkaloid extracted from Herba leonuri, leonurine (LE) has been found to be an effective natural active ingredient for inhibiting fibrosis in many preclinical experiments Literature References: Isoln from leaves of Leonurus sibiricus L., Labiatae: Kubota, Nakajima, C.A. 25, 771 (1931). Structure: Goto et al., Tetrahedron Lett. 1962. Chen Z , Song K , Li X , Wang L. Zhongguo Zhong Yao Za Zhi, 34 (12):1509-1511, 01 Jun 2009. Cited by: 1 article | PMID: 19777834. The structure and biological effect of leonurine. A uterotonic principle from the Chinese drug, I-mu Ts'ao. Yeung HW , Kong YC , Lay WP , Cheng KF Leonurine, supplied by Shanghai Yanyi Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and mor Nothing about the molecular structure of leonurine jumps out and barks drug-like to me. It might be a decent starting point for synthetic mescaline, but in no way worth the effort of methylating the 4-hydroxy group. Most of the limited anecdotal reports on the interweb describe a cannabinoimimetic psychical effect--I know from your posts.

Leonurine hydrochloride(CAS NO.24697-74-3) is one of the chemical constituents of the South African plant Leonotis leonurus.IT is also called 4-hydroxy-3,5-dimethoxybenzoic acid d-guanidinobutyl ester; syringic acid d-guanidinobutyl ester; [4-(4-hydroxy-3,5-dimethoxybenzoyloxy)butyl]guanidine; 4-guanidino-1-butanol syringate Leonurine is a pseudoalkaloid that has been isolated from Leonotis nepetifolia, Leonotis artemisia, Leonurus cardiaca (Motherwort), Leonurus sibiricus, as well as other plants of family Lamiaceae. 8 relations leonurine manufacturer/supplier, China leonurine manufacturer & factory list, find qualified Chinese leonurine manufacturers, suppliers, factories, exporters & wholesalers quickly on Made-in-China.com Leonurine significantly increased the viability of cardiomyocytes injured by hypoxia. In the leonurine-treated group, gene expression levels of pro-apoptotic genes, namely Bax and Fas, were significantly downregulated (by 0.95- and .72-fold, respectively; P < 0.001) compared with the hypoxic control group, whereas the expression of Bcl-2 and. Leonurine|cas 24697-74-3|Supplied by DC Che

Leonurine The Merck Index Onlin

Leonurine (SCM-198) | Autophagy Inhibitor | MedChemExpress

Of these, 10-methoxy-leonurine (1) and leonurine (2) exhibited IC 50 values of 7.4 ± 0.4 and 12.4 ± 0.8 μM, respectively, and acted as competitive inhibitors of tyrosinase, with K i values in the micromolar range. In silico modeling revealed a guanidine group located in the inner cavity and a benzene ring docked within the active site of. leonurine in rat biological samples such as plasma, urine, feces, and bile a er oral administrationusing HPLC/MS/MS method for the rst time. In the present study we aimed to characterize metabolite pro les of leonurine and to describe the possible metabolic pathways in rats. 2. Materials and Methods.. Chemicals and Reagents. Leonurine was. Third Party Contract Manufacturing (APIs and Excipients) Product Sourcing (APIs and Excipients) GDP Compliant Logistics; Securing of Supply Chains - 2nd Source

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Leonurine 100mg is available 1 time from Csnpharm labs CSN12376-100mg | Leonurine 100mg size: 100mg | 899.99 USD Catalog number CSN12376-100mg. 24697-74-3 - WNGSUWLDMZFYNZ-UHFFFAOYSA-N - Leonurine - Similar structures search, synonyms, formulas, resource links, and other chemical information Leonurine 50mg is available 1 time from Csnpharm labs CSN12376-50mg | Leonurine 50mg size: 50mg | 602.16 USD Catalog number CSN12376-50mg. Leonurina es uno de los componentes químicos de la planta sudafricana Leonotis leonurus.Es un alcaloide levemente psicoactiva encontrado en las especies Leonotis nepetifolia, Leonurus japonicus, Leonurus cardiaca, así como en otras plantas de la familia Lamiaceae.La leonurina se extrae fácilmente en agua, así como a partir del aceite esencial de Leonurus sibiricus Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory

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